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FLASH GENE
Symbol OLIG1 contributors: mct/shn - updated : 17-01-2024
HGNC name oligodendrocyte transcription factor 1
HGNC id 16983
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in oligodendroglial tumors and anaplastic astrocytomas
constitutional   amplification    
Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
constitutional   deletion    
in the cerebellum, deletion of both OLIG2 and OLIG1 results in impaired genesis of Purkinje cells (PCs) and Pax2(+) interneurons
Susceptibility susceptibility to multiple sclerosis
Variant & Polymorphism
Candidate gene OLIG1 protein expression could be utilized as a novel prognostic factor, which could aid in deciding which non-small cell lung cancer patients might benefit from more aggressive therapy
Marker
  • a molecular marker for human glial brain tumors
  • Therapy target
    ANIMAL & CELL MODELS
  • in Olig1(-/-)2(-/-) double-mutant mice motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished
  • Olig1 is triplicated and overexpressed in the Ts65Dn mouse forebrain (mouse models of Down syndrome) displaying cognitive deficits
  • Olig1-null neonatal mice showed significant hypomyelination after moderate neonatal stroke