Symbol
| OLIG1
| contributors: mct/shn - updated : 17-01-2024
|
HGNC name
| oligodendrocyte transcription factor 1
|
HGNC id
| 16983
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
|  
| --over
|  
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in oligodendroglial tumors and anaplastic astrocytomas | constitutional
|  
| amplification
|  
|  
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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome | constitutional
|  
| deletion
|  
|  
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in the cerebellum, deletion of both OLIG2 and OLIG1 results in impaired genesis of Purkinje cells (PCs) and Pax2(+) interneurons | |
Susceptibility
|
susceptibility to multiple sclerosis |
Variant & Polymorphism
|
| |
Candidate gene
| OLIG1 protein expression could be utilized as a novel prognostic factor, which could aid in deciding which non-small cell lung cancer patients might benefit from more aggressive therapy |
Marker
| a molecular marker for human glial brain tumors |
Therapy target
| |
| in Olig1(-/-)2(-/-) double-mutant mice motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished | |
Olig1 is triplicated and overexpressed in the Ts65Dn mouse forebrain (mouse models of Down syndrome) displaying cognitive deficits |
|
Olig1-null neonatal mice showed significant hypomyelination after moderate neonatal stroke |