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FLASH GENE
Symbol NCS1 contributors: mct - updated : 20-03-2019
HGNC name neuronal calcium sensor 1
HGNC id 3953
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
facilitates metastatic spread of liver and breast cancer
constitutional germinal mutation      
impairment of the normal cycling of NCS-1 by the R102Q mutation could have subtle effects on neuronal signalling and physiology in the developing and adult brain
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • cardiomyocytes derived from Ncs1-deficient (Ncs1-/-) mice were more susceptible to oxidative and metabolic stress than wild-type (WT) myocytes