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FLASH GENE
Symbol INVS contributors: mct - updated : 27-06-2019
HGNC name inversin
HGNC id 17870
ASSOCIATED DISORDERS
corresponding disease(s) NPHP2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
leads to impaired ventral extension and elongation of the early pronephros
constitutional       loss of function
decreases Na+ transport via SCNN1A, mediated in part by transcriptional and posttranslational regulation of CRTC2/SGK1/NEDD4L axis as a contributory mechanism for enlarged kidneys in NPHP2
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerlung 
serve as a novel therapeutic target of non-small cell lung cancer
ANIMAL & CELL MODELS
reversion of left-right asymetry in animal models associated with an anomaly of cilia motility