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FLASH GENE
Symbol KLF5 contributors: mct/pgu - updated : 03-03-2017
HGNC name Kruppel-like factor 5 (intestinal)
HGNC id 6349
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
frequent hemizygous deletion or loss of expression in breast cancer
tumoral     --low  
an LOH and loss of function in prostate cancer
tumoral     --low  
in intestinal tumors
tumoral        
silenced by hypermethylation in acute myeloid leukemia
tumoral     --low  
was lost concurrently with NOTCH1 in squamous cell cancers
Susceptibility
Variant & Polymorphism
Candidate gene may be a tumor suppressor gene in prostate cancer
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
FBXW7 tumor suppressor targeting KLF5 for ubiquitin-mediated degradation and suppression of breast cell proliferation, is a therapeutic target for breast cancer and other cancers
cardiovascular  
potential diagnostic biomarker and therapeutic target for cardiovascular diseases
cancerdigestiveoesophagus
KLF5 may be a useful diagnostic and therapeutic target in esophageal squamous carcinomas and possibly more generally in other cancers associated with TP53 loss of function
ANIMAL & CELL MODELS
  • Klf5 knockout mice, homozygous mutant died before embryonic day 8.5
  • Klf5 +/- mice showed diminished levels of arterial wall thickening angiogenesis, cardiac hypertrophy and intestinal fibrosis in response to external stress
  • Klf5 null mice were markedly deficient in white adipose tissue development