Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

KLF5

contributors: mct/pgu - updated : 03-03-2017

HGNC name	Kruppel-like factor 5 (intestinal)
HGNC id	6349

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     frequent hemizygous deletion or loss of expression in breast cancer tumoral     --low   an LOH and loss of function in prostate cancer tumoral     --low   in intestinal tumors tumoral         silenced by hypermethylation in acute myeloid leukemia tumoral     --low   was lost concurrently with NOTCH1 in squamous cell cancers

Susceptibility

Variant & Polymorphism

Candidate gene	may be a tumor suppressor gene in prostate cancer
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast FBXW7 tumor suppressor targeting KLF5 for ubiquitin-mediated degradation and suppression of breast cell proliferation, is a therapeutic target for breast cancer and other cancers cardiovascular     potential diagnostic biomarker and therapeutic target for cardiovascular diseases cancer digestive oesophagus KLF5 may be a useful diagnostic and therapeutic target in esophageal squamous carcinomas and possibly more generally in other cancers associated with TP53 loss of function

ANIMAL & CELL MODELS

	Klf5 knockout mice, homozygous mutant died before embryonic day 8.5
	Klf5 +/- mice showed diminished levels of arterial wall thickening angiogenesis, cardiac hypertrophy and intestinal fibrosis in response to external stress
	Klf5 null mice were markedly deficient in white adipose tissue development