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FLASH GENE
Symbol TACC3 contributors: mct/pgu - updated : 25-06-2013
HGNC name transforming, acidic coiled-coil containing protein 3
HGNC id 11524
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
in various cancer cell lines
tumoral     --over  
in multiple myeloma with t(4;14)(p16;q32)
tumoral     --low  
down-regulated by paclitaxel treatment in cervical cancer cells, overexpression of TACC3 may be associated with the mechanisms of chemoresistance, tumor progression, cell proliferation and metastasis
tumoral     --low  
reduced expression in follicular, papillary and anaplastic thyroid carcinomas
tumoral fusion      
of FGFR1 or FGFR3, to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively in glioblastoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
potential therapeutic target in cancer cells
cancerhemopathy 
is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
ANIMAL & CELL MODELS