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FLASH GENE
Symbol MAPK10 contributors: mct/pgu - updated : 20-06-2015
HGNC name mitogen-activated protein kinase 10
HGNC id 6872
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut
Susceptibility
Variant & Polymorphism
Candidate gene
Marker PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
Therapy target
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut
Susceptibility
Variant & Polymorphism
Candidate gene
Marker PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
Therapy target
ANIMAL & CELL MODELS
  • Jnk3 null mice showed an increase in pik3cb transcript and protein, together with an increase in PI3K activity and phosphorylation of AKT