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FLASH GENE
Symbol CDK8 contributors: shn/pgu - updated : 07-05-2019
HGNC name cyclin-dependent kinase 8
HGNC id 1779
ASSOCIATED DISORDERS
corresponding disease(s) MRSCF
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification --over  
colon cancers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • CDK8 may identify a subset of colon cancer patients with a poor prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting CDK8 therapeutically may specifically inhibit the stem-like properties of cancer cells
    cancer  
    potential target for developing novel CDK8 inhibitors in cancer therapeutics
    cancermetastases 
    blocking CDK8/19 specifically abrogates tumor cell invasion, changes in EMT-associated transcription factors
    ANIMAL & CELL MODELS
    ablation of the CDK8 kinase in mice results in lethality at the preimplantation stage