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FLASH GENE
Symbol GPNMB contributors: mct/npt - updated : 21-02-2018
HGNC name glycoprotein non-metastatic protein B
HGNC id 4462
ASSOCIATED DISORDERS
corresponding disease(s) ACDC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in aggressive breast cancers and capable of promoting breast cancer metastasis to bone
tumoral     --over  
in epithelial ovarian cancer
constitutional       gain of function
in Niemann-Pick type C (NPC) patients, most likely due to glycosphingolipids (GSLs) accumulation
Susceptibility
Variant & Polymorphism
Candidate gene for CYMD (cystoid macular dystrophy)
Marker
  • is a novel marker for obesity-induced adipose tissue macrophages (ATMs) infiltration and potentiator of interleukin-4 responses
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may serve as an attractive therapeutic target of cancer treatment
    neurologyneurodegenerative 
    can be a target for therapeutic intervention for suppressing motor neuron degeneration in ALS
    cancerreproductivebreast
    represents an attractive target for therapeutic intervention in breast cancer
    ANIMAL & CELL MODELS
  • Gpnmb deficiency attenuated the dilated cardiomyopathy in muscle lim protein knockout mice but could not prevent cardiac hypertrophy induced by isoprenaline infusion