Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ARAP1

contributors: mct/ - updated : 10-03-2014

HGNC name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
HGNC id	16925

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   is associated with increased risk of T2D

Susceptibility

to type 2 diabetes (T2D)

Variant & Polymorphism SNP	T2D-risk allele (C) of rs11603334 is associated with increased ARAP1 transcript levels in primary human pancreatic islets, disrupts binding of a protein complex containing transcriptional regulators, and increases transcriptional activity at the ARAP1 P1 promoter

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   ARAP1 antagonists might hold important therapeutic potential

ANIMAL & CELL MODELS