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FLASH GENE
Symbol TRIM32 contributors: mct/npt/pgu - updated : 27-11-2018
HGNC name tripartite motif-containing 32
HGNC id 16380
ASSOCIATED DISORDERS
corresponding disease(s) LGMD2H , BBS11
related resource Limb-Girdle Muscular Dystrophy pages
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
were detected in gastric cancer tissues
      --low  
in atopic dermatitis skin compared with healthy control and psoriatic skin suggest a defective TRIM32 pathway in atopic dermatitis pathogenesis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • TRIM32 expression levels may be of potential prognostic value in gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential therapeutic target for developmental disorders and RA-dependent leukemias
    neuromuscularmyopathy 
    is a possible therapeutic target to favor skeletal muscle regeneration in DMD patients
    ANIMAL & CELL MODELS
  • histological analysis of T32KO (Trim32 knock-out model) skeletal muscles revealed mild myopathic changes, electron microscopy showed areas with Z-line streaming and a dilated sarcotubular system with vacuoles -- the latter being a prominent feature of sarcotubular myopathy
  • Trim32-null mice showed a decrease in the concentration of neurofilament proteins in the brain and a reduced motoraxon diamete
  • Trim32-/- mice produced higher levels of serum inflammatory cytokines and were more sensitive to loss of body weight and inflammatory death upon Salmonella typhimurium infection