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FLASH GENE
Symbol CLEC4M contributors: mct/npt - updated : 28-02-2009
HGNC name C-type lectin domain family 4, member M
HGNC id 13523
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to SARS-CoV (coronavirus) infection
Variant & Polymorphism repeat homozygosity for tandem repeats plays a protective role during SARS infection, homozygosity for VNTR in exon 4 were protected against SARS coronavirus infection (protective effect was due to formation of a homotetramer, with apparently higher affinity for viral ligands, in homozygous subjects)
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Clec4m helps to condition dendritic cells (DCs) in the gastrointestinal lamina propria (LPDCs) for the induction of oral tolerance in a model of food-induced anaphylaxis