Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SIRT3

contributors: mct/pgu - updated : 15-10-2016

HGNC name	sirtuin 3
HGNC id	14931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in skeletal muscle in states of diabetes and obesity is an important component of the pathogenesis of type 2 diabetes, which can induce altered mitochondrial function, increase ROS production and oxidative stress, and lead to insulin resistance

Susceptibility

to survival at oldest age to metabolic syndrome

Variant & Polymorphism SNP , repeat	VNTR with enhancer activity associated to longevity
	SNP in SIRT3 gene is suggestive of a genetic association with the metabolic syndrome

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	SIRT3-deficient mice exhibit striking mitochondrial protein hyperacetylation
	Sirt3 plays an essential role in the Caloric restriction-mediated prevention of age-related cochlear cell death and hearing loss in mice
	Sirt3 knockout mice exhibit decreased oxygen consumption and develop oxidative stress in skeletal muscle, leading to JNK activation and impaired insulin signaling
	mice lacking Sirt3 (Sirt3KO) placed on a high-fat diet show accelerated obesity, insulin resistance, hyperlipidemia, and steatohepatitis compared to wild-type