Symbol
| PDLIM1
| contributors: mct/pgu - updated : 03-07-2018
|
HGNC name
| PDZ and LIM domain 1 (elfin)
|
HGNC id
| 2067
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
up-regulated in dorsal root ganglion neurons and facial motoneurons after nerve injury | constitutional
|  
|  
|  
| loss of function
|
results in markedly enhanced platelet activation in response to collagen and a prothrombotic phenotype | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| PDLIM1 loss in metastatic tissues may represent a potential prognostic marker of aggressive disease | Therapy target
|
System | Type | Disorder | Pubmed |
blood | coagulation | | |
might provide a basis for the development of novel strategies to control intravascular platelet activation |
| | |