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FLASH GENE
Symbol PDLIM1 contributors: mct/pgu - updated : 03-07-2018
HGNC name PDZ and LIM domain 1 (elfin)
HGNC id 2067
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
up-regulated in dorsal root ganglion neurons and facial motoneurons after nerve injury
constitutional       loss of function
results in markedly enhanced platelet activation in response to collagen and a prothrombotic phenotype
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • PDLIM1 loss in metastatic tissues may represent a potential prognostic marker of aggressive disease
  • Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    might provide a basis for the development of novel strategies to control intravascular platelet activation
    ANIMAL & CELL MODELS