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FLASH GENE
Symbol COPS5 contributors: mct/ - updated : 28-05-2018
HGNC name COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
HGNC id 2240
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in several cancer cells
tumoral     --over  
may indicate a poor prognosis for patients with esophageal squamous cell carcinoma
tumoral     --over  
in human hepatocellular carcinoma
constitutional     --over  
of COPS5 levels in the Alzheimer brain may increase the levels of RANBP9 and, consequently, APP levels
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
potential target for cancer therapy
cancerdigestiveliver
maybe an attractive molecular target for systemic Hepatocellular carcinoma therapy
neurologyneurodegenerativealzheimer
lowering COPS5 levels may be an effective therapeutic approach for AD
ANIMAL & CELL MODELS
defects in DSB repair in Jab1 gene-targeted embryos contribute to premature cell death in homozygous Jab1 knockout mice