Symbol
| COPS5
| contributors: mct/ - updated : 28-05-2018
|
HGNC name
| COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
|
HGNC id
| 2240
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
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in several cancer cells | tumoral
|  
|  
| --over
|  
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may indicate a poor prognosis for patients with esophageal squamous cell carcinoma | tumoral
|  
|  
| --over
|  
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in human hepatocellular carcinoma | constitutional
|  
|  
| --over
|  
|
of COPS5 levels in the Alzheimer brain may increase the levels of RANBP9 and, consequently, APP levels | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
potential target for cancer therapy | cancer | digestive | liver | |
maybe an attractive molecular target for systemic Hepatocellular carcinoma therapy
| neurology | neurodegenerative | alzheimer | |
lowering COPS5 levels may be an effective therapeutic approach for AD |
| | | |
| defects in DSB repair in Jab1 gene-targeted embryos contribute to premature cell death in homozygous Jab1 knockout mice |