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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CXCL13

contributors: mct/npt/pgu - updated : 25-06-2010

HGNC name	chemokine (C-X-C motif) ligand 13
HGNC id	10639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   with its receptor, CXCR5 in B-cell chronic lymphocytic leukemia tumoral     --over   in breast cancer, significantly elevated serum concentrations of CXCL13 in patients with metastatic disease

Susceptibility

to ulcerative colitis

Variant & Polymorphism

Candidate gene
Marker	prognostic marker for oral squamous cell carcinoma development and progression
	marker that appears to be helpful in clinically atypical cases of Lyme neuroborreliosis, and, in particular, in early stages of the disease when the B burgdorferi AI is (still) negative
Therapy target
	System Type Disorder Pubmed cancer reproductive breast might serve as a useful therapeutic target and/or diagnostic marker in this malignancy cancer head and neck   potential therapeutic target to prevent oral squamous cell carcinoma bone invasion/osteolysis

ANIMAL & CELL MODELS

blc knock out mice