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Symbol TRPV1 contributors: shn/npt/pgu - updated : 27-02-2016
HGNC name transient receptor potential cation channel, subfamily V, member 1
HGNC id 12716
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
expressed in synovial fibroblasts from osteoarthritis and rheumatoid arthritis patients
constitutional     --over  
in injured brachial plexus nerves
constitutional     --low  
in nerve fibres in diabetic neuropathy skin that may result from the known decrease of nerve growth factor (NGF) levels
constitutional     --over  
in TRPV1 mRNA expression in dorsal root ganglion neurons after injection of complete Freund adjuvant (CFA)-induced inflammation
constitutional       gain of function
may contribute to preferential neuronal stress in large dorsal root ganglion neurons relatively early in diabetic sensory neuropathy
constitutional     --over  
in hypertrophic hearts, and development of heart hypertrophy is directly associated with increased TRPV1 expression
Susceptibility rectal hypersensitivity
Variant & Polymorphism
Candidate gene
Therapy target
antagonizing the TRPV1-AKAP5 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia
more selective therapeutic target than other TRPs for pain and hypersensitivity, particularly in post-traumatic neuropathy
antagonising TRPV1 sensitisation is a promising approach and should receive more attention in future research as well as in the development of anti-migraine drugs
TRPV1 and TRPV2 channels are targets for therapeutic agents of cardiovascular diseases
TRPV1 could be a new therapeutic target for treating muscle atrophy
  • Vr1-/- mice were viable, fertile, and largely indistinguishable from wildtype littermates but sensory neurons from these mice are severely deficient in their responses to vanilloid compounds, protons, or heat greater than 43 degrees C
  • Trpv1-null mice had more frequent low-amplitude bladder activity than normal mice
  • Trpv1-/- mice had enhanced insulin sensitivity
  • mice lacking Trpv1 pain receptors are long-lived, displaying a youthful metabolic profile at old age