Variant & Polymorphism
SNP
| SNP1, SNP2, SNP3, polymorphism T1131>C and S19>W variant, c.553G>T, associated with hypertriglyceridemia |
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S19W polymorphism is likely to be functional and explain the strong association of this variant with plasma triglycerides |
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variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels |
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1131T>C SNP, modulates the effect of fat intake on BMI and obesity risk in both men and women |
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APOA5 rs662799 is associated with metabolic syndrome |
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APOA5 variants cause hypertriglyceridemia |
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hypertriglyceridemic patients carrying the APOA5 -1131T>C polymorphism exhibited increased atherogenic LDL levels and arterial stiffness, probably due to an effect of the -1131T>C polymorphism on apoA5 concentrations |
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