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FLASH GENE
Symbol TAF4B contributors: mct - updated : 21-05-2016
HGNC name TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
HGNC id 11538
ASSOCIATED DISORDERS
corresponding disease(s) SPGF13
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
homozygous truncating mutations p.R611X in TAF4B in azoospermia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • TAFII 105defective mice, display a defect in ovarian development (folliculogenesis)
  • rapid decline of ovarian function in Taf4b-null mice begins in early postnatal life, and follicle depletion is completed by 16 wk of age
  • severe deficits in prophase I progression as well as asynapsis in murine Taf4b-deficient oocytes