Symbol
| TAF4B
| contributors: mct - updated : 21-05-2016
|
HGNC name
| TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
|
HGNC id
| 11538
|
corresponding disease(s)
|
SPGF13
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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constitutional
| germinal mutation
|  
|  
|  
|
homozygous truncating mutations p.R611X in TAF4B in azoospermia | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| TAFII 105defective mice, display a defect in ovarian development (folliculogenesis) | |
rapid decline of ovarian function in Taf4b-null mice begins in early postnatal life, and follicle depletion is completed by 16 wk of age |
|
severe deficits in prophase I progression as well as asynapsis in murine Taf4b-deficient oocytes |