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FLASH GENE
Symbol BCL3 contributors: mct - updated : 07-07-2010
HGNC name B-cell CLL/lymphoma 3
HGNC id 998
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
in chronic lymphocytic leukemia and non Hodgkin lymphoma in t(14;19)(q32-q13)
constitutional     --over  
increases apoptosis
tumoral     --over  
in human myeloma cells is associated with increased proliferation and inferior prognosis
Susceptibility to Crohn disease
Variant & Polymorphism SNP
  • rs2927488 in BCL3 significantly associated with Crohn disease (Pubmed 20601676)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS