Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LONP1 contributors: mct - updated : 26-01-2017
HGNC name lon peptidase 1, mitochondrial
HGNC id 9479
ASSOCIATED DISORDERS
corresponding disease(s) CODAS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
is a poor prognosis marker in human colorectal cancer and melanoma
Susceptibility to Congenital diaphragmatic hernia (CDH)
Variant & Polymorphism other
  • CDH probands with LONP1 variants had higher mortality in the neonatal period compared with other children with CDH
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inactivation of Lonp1 in mouse embryonic lung epithelium leads to disrupted lung development and full lethality at birth