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FLASH GENE
Symbol BRD4 contributors: mct/pgu - updated : 29-12-2017
HGNC name bromodomain containing 4
HGNC id 13575
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
translocated t(15;19) (q13;p13.1) in upper respiratory tract carcinoma (fusion with NUT), highly lethal carcinoma
tumoral   translocation    
t(14;19)(q32;p13), recurrent translocation in B cell malignancies, fusion of Ig heavy-chain (IGH@)-variable region with BRD4
tumoral        
BRD4 activation in breast carcinomas induces a gene expression profile predictive of breast cancer outcome
tumoral     --other  
aberrant expression of BRD4 in thyroid cancer is possibly involved in tumor progression
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
inhibition of BRD4 is a promising therapeutic strategy in AML (acute myeloid leukaemia) and, potentially, other cancers
cancerhemopathy 
small molecule inhibitor of BRD4, has profound efficacy against human and murine MLL-fusion leukaemic cell lines, through the induction of early cell cycle arrest and apoptosis
cancerdigestiveliver
is a potential novel target for the development of therapeutic approaches against HCC
ANIMAL & CELL MODELS
  • Brd4-depleted mice display reversible epidermal hyperplasia, alopecia, and decreased cellular diversity and stem cell depletion in the small intestine