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FLASH GENE
Symbol CDC73 contributors: mct/pgu - updated : 02-05-2012
HGNC name cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
HGNC id 16783
ASSOCIATED DISORDERS
corresponding disease(s) HRPT2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation LOH    
in hyperparathyroidism-jaw tumor(HPT-JT)
tumoral somatic mutation      
in sporadic parathyroid carcinoma
tumoral germinal mutation      
in sporadic parathyroid carcinoma
tumoral       loss of function
in parathyroid and jaw fibroma
tumoral       loss of function
critically facilitates malignant transformation
tumoral   LOH    
in clear cell, papillary, chromophobe renal cell carcinomas, oncocytomas and Wilms tumors
tumoral     --low  
is involved in the pathogenesis of parathyroid, breast, and gastric carcinomas
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS