Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SPRY2 contributors: mct - updated : 07-01-2018
HGNC name sprouty homolog 2 (Drosophila)
HGNC id 11270
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
by hypermethylation of CpG island in invasive prostate carcinoma cell lines and high-grade clinical cancer (compared to benign prostatic hyperplasia (BPH) and well-differentiated tumours)
tumoral     --low  
in hepatocellular carcinoma
constitutional     --over  
induces neuronal cell death, whereas its inhibition favors neuronal survival
tumoral     --low  
in breast, lung and prostate cancer, and in melanoma
tumoral       gain of function
in undifferentiated high-grade tumours and at the invasive front of low-grade carcinomas
Susceptibility
Variant & Polymorphism
Candidate gene for cleft lip/palate; for lens cell proliferation and congenital cataract in del 13q
Marker
  • candidate novel marker for high-grade tumours
  • Therapy target
  • target of therapeutic intervention in colon cancer
  • ANIMAL & CELL MODELS