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FLASH GENE
Symbol AATF contributors: mct - updated : 23-09-2015
HGNC name apoptosis antagonizing transcription factor
HGNC id 19235
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in colon and kidney carcinoma
tumoral     --over  
overexpressed ubiquitously in all the leukemic cell lines
constitutional       loss of function
mediates a self-perpetuating cycle of cell death
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
attractive, still theoretical, therapeutic target for cancer treatments
cancer  
AATF-silencing can be used to induce apoptosis and regulate ER expression in breast cancer cells for therapeutic interventions.
ANIMAL & CELL MODELS
  • exposure of Aatf(+/-) mice to ionizing radiations resulted in enhanced apoptosis of thymocytes, compared with WT mice