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FLASH GENE
Symbol FGF21 contributors: mct/pgu - updated : 05-05-2016
HGNC name fibroblast growth factor 21
HGNC id 3678
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in diabetic subjects after metformin therapy
constitutional     --over  
in hypertension, atherosclerosis and coronary artery disease
constitutional     --over  
during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT and LEPROTL1
constitutional     --over  
during chronic food restriction is associated with reduced bone growth and growth hormone (GH) insensitivity
constitutional     --over  
may directly suppress growth plate chondrocyte proliferation and differentiation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • serum FGF21 can be potentially used as a biomarker for nonalcoholic fatty liver disease
  • sensitive biomarker of mitochondrial disease
  • Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    attractive therapeutic agent to treat type 2 diabetes and the associated metabolic syndrome
    diabete  
    administration of FGF21 can be beneficial in treating hyperglycemia and insulin resistance
    diabetetype 2 
    FGF19 may serve as an ideal complement for FGF21 in diabetes therapy development
    ANIMAL & CELL MODELS
  • fgf21(-/-) mice exhibit an increased relative heart weight and develop enhanced signs of dilatation and cardiac dysfunction in response to isoproterenol infusion, indicating eccentric hypertrophy development