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FLASH GENE
Symbol ASAP1 contributors: mct - updated : 19-09-2017
HGNC name ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
HGNC id 2720
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
aberrantly expressed in invasive phenotypes of primary tumors of the breast
tumoral     --over  
in invasive breast cancer and in other types of invasive and malignant tumors, such as uveal melanomas
tumoral     --over  
in epithelial ovarian cancer (EOC)
Susceptibility to tuberculosis (tB)
Variant & Polymorphism other
  • association between TB and variants located in introns of the ASAP1 gene
  • Candidate gene strongly upregulated in a variety of tumors, expression correlating with poor metastasis-free survival and prognosis in colorectal cancer patients
    Marker
  • may be used as a biomarker in predicting patient outcome in epithelial ovarian cancer (EOC) patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    therapeutic target and/or biomarker for metastatic disease
    ANIMAL & CELL MODELS