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FLASH GENE
Symbol HAMP contributors: mct/npt/pgu - updated : 15-12-2014
HGNC name hepcidin antimicrobial peptide
HGNC id 15598
ASSOCIATED DISORDERS
corresponding disease(s) HFE2B
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
inheritance of digenic mutations in HAMP and HFE results in different types of hemochromatosis
constitutional     --low  
deficiency leads to hemochromatosis
constitutional     --over  
causes anemia of inflammation
tumoral     --low  
in hepatocellular carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • overexpressed in mouse during iron overload
  • constitutive expression of HAMP prevents iron overload in a mouse model of hemochromatosis