Symbol
| HAMP
| contributors: mct/npt/pgu - updated : 15-12-2014
|
HGNC name
| hepcidin antimicrobial peptide
|
HGNC id
| 15598
|
corresponding disease(s)
|
HFE2B
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
| germinal mutation
|  
|  
|  
|
inheritance of digenic mutations in HAMP and HFE results in different types of hemochromatosis | constitutional
|  
|  
| --low
|  
|
deficiency leads to hemochromatosis | constitutional
|  
|  
| --over
|  
|
causes anemia of inflammation | tumoral
|  
|  
| --low
|  
|
in hepatocellular carcinoma | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| overexpressed in mouse during iron overload | |
constitutive expression of HAMP prevents iron overload in a mouse model of hemochromatosis |