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FLASH GENE
Symbol SMAD3 contributors: mct/ - updated : 06-04-2018
HGNC name SMAD family member 3
HGNC id 6769
ASSOCIATED DISORDERS
corresponding disease(s) LDS3 , TAAD5
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
in acute T-cell lymphoblastic leukemia and in gastric carcinoma in the early stage
constitutional     --low  
accelerates not only cutaneous wound healing and keratinocyte proliferation but also colonic epithelial cell proliferation
constitutional     --over  
upregulation of ZFYVE9 and SMAD3 in cortex neurons might be involved in the development of intractable temporal lobe epilepsy
Susceptibility to osteoarthritis
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabete  
inhibition of SMAD3 function has therapeutic potential for diabetic renal disease
ANIMAL & CELL MODELS
  • Smad3 -/- mice showed an increased number of proliferating epithelial cells with activation of the Wnt/beta-catenin pathway in the colonic crypts
  • mice lacking Smad3 are protected against tubulointerstitial fibrosis following unilateral ureteral obstruction as evidenced by blocking of EMT and abrogation of monocyte influx and collagen accumulation