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FLASH GENE
Symbol CFL1 contributors: mct/shn/pgu - updated : 20-11-2018
HGNC name cofilin 1 (non-muscle)
HGNC id 1874
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
cofilin aggregation may contribute to neurodegeneration and brain aging by blocking intracellular trafficking and inducing synaptic loss
tumoral     --over  
significant association between overexpression of nuclear CFL1 with bladder cancer progression
tumoral     --over  
simultaneous overexpression of AURKA and CFL1 correlated with lymph node metastasis in thyroid cancer tissue
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • not only the higher levels of CFL1, but also its nuclear localization can be proposed as marker of worse outcome of patients with melanoma
  • positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer
  • cytoskeletal cofilin is potential tumor marker of invasive bladder cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    targetable platforms for the treatment of invasive bladder cancer
    cancerendocrinethyroid
    possibility of targeting AURKA and CFL1 for more effective treatment of thyroid cancer
    cancerhemopathy 
    targeting CFL1 might therefore provide another novel approach for treatment of Ewing sarcoma
    ANIMAL & CELL MODELS
  • Loss of n-cofilin impairs radial migration, resulting in the lack of intermediate cortical layers