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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CFL1

contributors: mct/shn/pgu - updated : 20-11-2018

HGNC name	cofilin 1 (non-muscle)
HGNC id	1874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   cofilin aggregation may contribute to neurodegeneration and brain aging by blocking intracellular trafficking and inducing synaptic loss tumoral     --over   significant association between overexpression of nuclear CFL1 with bladder cancer progression tumoral     --over   simultaneous overexpression of AURKA and CFL1 correlated with lymph node metastasis in thyroid cancer tissue

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	not only the higher levels of CFL1, but also its nuclear localization can be proposed as marker of worse outcome of patients with melanoma
	positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer
	cytoskeletal cofilin is potential tumor marker of invasive bladder cancer
Therapy target
	System Type Disorder Pubmed cancer urinary   targetable platforms for the treatment of invasive bladder cancer cancer endocrine thyroid possibility of targeting AURKA and CFL1 for more effective treatment of thyroid cancer cancer hemopathy   targeting CFL1 might therefore provide another novel approach for treatment of Ewing sarcoma

ANIMAL & CELL MODELS

Loss of n-cofilin impairs radial migration, resulting in the lack of intermediate cortical layers