Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PICALM contributors: mct - updated : 23-05-2014
HGNC name phosphatidylinositol binding clathrin assembly protein
HGNC id 15514
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with MLLT10 in acute lymphoblastic,myeloblastic leukemia with translocation t(10;11)(p13;q14) and t(10;11) (p13;q21) and in megakaryoblastic leukemia
Susceptibility to Alzheimer disease
Variant & Polymorphism other
  • polymorphisms increasing the risk of Alzheimer disease
  • SNPs in PICALM, in association with APOE epsilon4 homozygotes associated to familial late-onset Alzheimer disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS