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FLASH GENE
Symbol CCL3L1 contributors: SGE/npt - updated : 13-07-2010
HGNC name chemokine (C-C motif) ligand 3-like 1
HGNC id 10628
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to HIV/acquired immunodeficiency syndrome (AIDS)
Variant & Polymorphism other
  • a low copy number is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility
  • lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C (Grünhage 2010)
  • CCR5-59029 AG genotype and CCL3L1 gene dose appear to have synergistic or interactive effects and are expected to be involved in the host innate resistance to HIV-1 infection (Rathore 2009)
  • copy number of CCL3L1 influences risk of systemic lupus erythaematosus (SLE) and modifies the SLE-influencing effects associated with the CCR5 genotypes (Mamtani 2008)
  • Candidate gene
    Marker
    Therapy target
  • CCL3L1-CCR5 variations may be useful in identifying patients requireng earlier initiation of highly active antiretroviral therapy (Ahuja 2008)
  • ANIMAL & CELL MODELS