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FLASH GENE
Symbol APLNR contributors: mct/npt - updated : 24-03-2020
HGNC name apelin receptor
HGNC id 339
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in aortic valve stenosis, of the apelin-APLNR signaling pathway (Peltonen 2009)
constitutional     --low  
with increasing age
constitutional       loss of function
confers resistance to chronic pressure overload by markedly reducing myocardial hypertrophy and heart failure
Susceptibility to brain infarction
Variant & Polymorphism SNP SNP in the 5'-flanking region (SNP30, rs9943582, 154G/A) is significantly associated with brain infarction
Candidate gene
Marker
  • APLNR expression in tumour vasculature and tumour cells is an independent prognostic factor for survival of patients with clear-cell Renal cell carcinoma
  • Therapy target
  • apelin-APLNR signaling pathway, is a possible novel target for drug discovery in calcified aortic valve disease by suppressing chemotaxis, angiogenesis and osteoblast activity, all of which are well-documented phenomena in the disease process (Peltonen 2009)
  • APELIN/APLNR system might become a novel promising therapeutic target for anti-aging
  • SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    promising potential as a therapeutic target for treatment of neuropathy
    psychiatry  
    promising potential as a therapeutic target for treatment of psychosis
    miscelleaneousvascular 
    apelin/APLNR system is a promising target for managing vascular disease
    miscelleaneouspain 
    may provide novel pharmacological interventions for neuropathic pain
    cardiovascularaquiredheart failure
    important therapeutic target for the treatment of heart failure, hypertension
    ANIMAL & CELL MODELS