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FLASH GENE
Symbol GRB7 contributors: mct - updated : 24-09-2013
HGNC name growth factor receptor-bound protein 7
HGNC id 4567
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
plays pivotal roles in activating signal transduction and promoting tumor growth in breast cancer cells with chromosome 17q11-21 amplification
tumoral     --over  
in invasive esophageal carcinomas
tumoral   amplification    
with ERBB2 in primary gastric cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancermetastases 
GRB7 peptide inhibitor appears to be a promising molecularly targeted therapeutic agent against metastatic pancreatic cancer
cancer  
has potential to be developed as a therapeutic agent alone, in combination with traditional chemotherapy, or in combination with other targeting molecules, in several cancer
ANIMAL & CELL MODELS