Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SLC12A1

contributors: mct/pgu - updated : 10-05-2016

HGNC name	solute carrier family 12 (sodium/potassium/chloride transporters), member 1
HGNC id	10910

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BSND1 , NHPT1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with LEO1 in gliomas constitutional     --low   through inhibitory factors for SLC12A1 expression in dehydration constitutional       gain of function is linked with inherited hypertension

Susceptibility

to essential hypertension

Variant & Polymorphism other	rare alleles protecting against essential hypertension

Candidate gene
Marker
Therapy target	target of loop diuretic drugs used worldwide for the treatment of edematous states
	System Type Disorder Pubmed miscelleaneous urinary   target of loop diuretic drugs used worldwide for the treatment of edematous states

ANIMAL & CELL MODELS