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FLASH GENE
Symbol WNT2B contributors: mct - updated : 04-09-2018
HGNC name wingless-type MMTV integration site family, member 2B
HGNC id 12781
ASSOCIATED DISORDERS
corresponding disease(s) DIAR9
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in several breast cancer cell lines
constitutional       gain of function
abnormal upregulation in the levels of WNT2B and WNT7B in neural tube defects (NTDs)
tumoral     --over  
of GLI1 and WNT2B might play a pivotal role during tumorigenesis of pancreatic cancer, and the high expression of WNT2B might be associated with poor prognosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length