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FLASH GENE
Symbol STMN1 contributors: shn/mct - updated : 30-03-2017
HGNC name stathmin 1
HGNC id 6510
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in neuroblastoma, melanoma and acute leukemia
constitutional       gain of function
aberrantly upregulated in in SMA, leading to a decreased level of polymerized tubulin, which was correlated with disease severity (Wen 2010)
tumoral     --over  
in pancreatic cancer tissues and high expression of stathmin was correlated with vascular emboli, tumor size, and overall survival
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • SIVA1 and STMN1 may be biomarkers for breast cancer
  • could serve as a potential prognostic marker for patients with in non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    SIVA1 and STMN1 may be therapeutic targets for breast cancer
    neuromuscularlaterale amyotrophy sclerosis 
    inhibition of stathmin expression in SMA diminished the SMA phenotype, these results suggest that microtubule dynamics may be a potential therapeutic target and could provide a novel avenue for SMA therapy
    cancerbrain 
    modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
    ANIMAL & CELL MODELS
  • deficiency in fear processing in stathmin(-/-) female mice leads to improper threat assessment and profound deficiency is observed in maternal behavior as well