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FLASH GENE
Symbol OAS1 contributors: mct - updated : 11-04-2018
HGNC name 2',5'-oligoadenylate synthetase 1, 40/46kDa
HGNC id 8086
ASSOCIATED DISORDERS
corresponding disease(s) PAPHG
Susceptibility
  • host susceptibility to viral infection
  • to multiple sclerosis (MS)
  • to prostate cancer
  • to Sjögren's syndrome (SS)
  • Variant & Polymorphism SNP , other
  • influencing host susceptibility to viral infection
  • association between rs10774671 and MS
  • significant association was observed between the rs2660 genotype (A/G) and prostate cancer
  • is a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS