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FLASH GENE
Symbol RARA contributors: mct/ - updated : 13-06-2014
HGNC name retinoic acid receptor, alpha
HGNC id 9864
ASSOCIATED DISORDERS
corresponding disease(s) RARA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
PML-RARalpha fusion alone can confer properties of self-renewal to committed hematopoietic progenitors before the onset of acute promyelocytic leukemia
tumoral fusion      
STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding
tumoral fusion      
fusion partner of BCOR in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia
Susceptibility
  • to obesity
  • to meningomyelocele (MM)
  • Variant & Polymorphism SNP
  • rs12051734 conferred a protective effect for MM susceptibility (MID: 21254357)
  • Candidate gene for isolated cleft lip/palate
    Marker
    Therapy target PML-RARA degradation or therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells
    ANIMAL & CELL MODELS