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FLASH GENE
Symbol PARP1 contributors: mct/ - updated : 11-12-2017
HGNC name poly (ADP-ribose) polymerase 1
HGNC id 270
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in NPM-ALK positive anaplastic large cells lymphoma
constitutional     --over  
early stage of diseased tricuspid valves exhibited higher mRNA levels for PARP1 compared to bicuspid valves
Susceptibility
  • to breast cancer
  • to Parkinson disease (PD)
  • Variant & Polymorphism SNP
  • increasing the risk of breast cancer
  • variations in the regulatory region of PARP1 gene might modify the risk for PD
  • Candidate gene
  • may participate in the pathophysiology of type I diabetes
  • may be site of mutation in Fanconi anemia
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    synthetic lethal therapeutic strategy for cancer treatment using PARP1 inhibitors
    cardiovascularatheroma 
    inhibition of PARP1 may represent a promising therapeutic target in atherosclerosis
    cancer  
    link between the PARP1 and G-quadruplex ligands and excellent efficacy of a multi-component strategy based on the use of PARP inhibitors in telomere-based therapy in cancer
    cancer  
    co-targeting PARP1 and KLF8 (or other potential PARP1-interacting KLFs) as a novel anti-cancer therapeutic strategy
    cancer  
    (PARP1) inhibitors are emerging as an important class of drugs for treating BRCA-deficient cancers
    cardiovascularvalvulopathy 
    potential therapeutic target in aortic stenosis
    ANIMAL & CELL MODELS