Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TSHR | contributors: mct/npt - updated : 25-08-2009 |
HGNC name | thyroid stimulating hormone receptor |
HGNC id | 12373 |
|
ASSOCIATED DISORDERS |
corresponding disease(s) | TSHR , GHTF , HFTA |
related resource | TSH Receptor mutation database |
Susceptibility | to Graves disease (GD) |
Variant & Polymorphism SNP | SNPs within a 40 kb region of TSHR intron 1 are highly associated with GD (Brand 2009) |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |
in a mouse model of Graves disease, goiter and hyperthyroidism occurred to a significantly greater extent when the adenovirus expressed the free alpha subunit as opposed to a genetically modified TSHR that cleaves minimally into subunits | |
|