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FLASH GENE
Symbol SPI1 contributors: mct - updated : 24-10-2017
HGNC name spleen focus forming virus (SFFV) proviral integration oncogene spi1
HGNC id 11241
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in acute myeloid leukemia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
immunologyinflammatory 
is a potential target for the treatment of immune-related diseases
ANIMAL & CELL MODELS
  • mice deficient in both Spib and Spi1 in the B-cell lineage had reduced frequencies of B cells as well as impaired B-cell differentiation, and developed pre-B cell acute lymphoblastic leukemia before 30 weeks of age