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FLASH GENE
Symbol ALDH2 contributors: mct/npt - updated : 29-06-2010
HGNC name aldehyde dehydrogenase 2 family (mitochondrial)
HGNC id 404
ASSOCIATED DISORDERS
corresponding disease(s)
related resource Human Polymorphisms of ALDH Genes
Susceptibility
  • to alcoholism when associated with ADA2 polymorphism
  • to myocardial infarction
  • to esophageal cancer in heavy drinking patients
  • to alcohol-induced flushing
  • to genotoxicity induced by alcohol drinking
  • to esophageal squamous cell carcinoma (ESCC)
  • Variant & Polymorphism SNP , other
  • GLU 487 LYS increased risk of esophageal cancer in heavy drinking patients
  • SNP rs671, alcohol drinking, and smoking are independent risk factors for ESCC (Cui 2009)
  • associations between ADH1B/ALDH2 polymorphisms and genotoxicity in alcohol drinkers (Ishikawa 2007)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS