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Symbol SERPINB5 contributors: mct/pgu - updated : 30-04-2010
HGNC name serpin peptidase inhibitor, clade B (ovalbumin), member 5
HGNC id 8949
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
frequently in advanced cancer with metastases
tumoral     --over  
in high-grade prostate intraepithelial neoplasia (HGPIN)
tumoral     --low  
by hypermethylation in papillary thyroid carcinomas
tumoral     --over  
in lung cancer (squamous cell carcinomas) and in preneoplastic bronchial lesions
tumoral     --over  
by hypomethylation in a large fraction of pancreatic cancer cell lines and primary pancreatic carcinomas
Variant & Polymorphism
Candidate gene
  • increased expression of SERPINB5 is associated with metastasis of hepatocellular carcinoma
  • detection of SERPINB5 in blood may indicate aggressive disease in breast cancer
  • Marker
  • may be a useful marker to identify the potential for progression in oral squamous cell carcinoma
  • cytoplasmic mSERPINB5 may play an important role in lung carcinomas by regulating apoptosis and thus is a favorable prognostic marker for adenocarcinoma patients whereas nuclear localization may be linked to promotion of angiogenesis
  • Therapy target