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FLASH GENE
Symbol PRKAA2 contributors: shn/ - updated : 10-04-2015
HGNC name protein kinase, AMP-activated, alpha 2 catalytic subunit
HGNC id 9377
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
  • significantly associated with serum lipoproteins in a large sample of normal female Caucasians
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • variants are significantly associated with serum lipoproteins in a large sample of normal female Caucasians (variants are significantly associated with serum
  • lipoproteins in a large sample of normal female Caucasians)
  • SNP influencing insulin resistance and susceptibility to type 2 diabetes in the Japanese population
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    interaction between AMPK and CLIP-170 might be a therapeutic target for treatment of conditions such as cancer, tumour angiogenesis and neointimal hyperplasia
    ANIMAL & CELL MODELS
  • AMPKalpha2(-/-) mice display high glucose levels in the fed period and during an oral glucose challenge associated with low insulin plasma levels and have reduced insulin-stimulated whole-body glucose utilization