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FLASH GENE
Symbol FCGR3B contributors: mct - updated : 23-12-2015
HGNC name Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
HGNC id 3620
ASSOCIATED DISORDERS
corresponding disease(s) FCGR3B
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional        
low copy number was associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus
constitutional     --low  
may be a common genomic mechanism in the development of SLE, Wegener's granulomatosis and microscopic polyangiitis
constitutional   deletion    
juxtaposes the 5prime-regulatory sequences of FCGR2C with the coding sequence of FCGR2B, creating a chimeric gene that provides an explanation for SLE risk associated with reduced FCGR3B gene copy number
constitutional   deletion    
is a risk factor for systemic sclerosis
Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to systemic lupus erythematosus, primary Sjogren syndrome (pSS), and Wegener granulomatosis (WG)
  • to idiopathic pulmonary fibrosis
  • to non-organ-specific autoimmune diseases
  • Variant & Polymorphism other
  • reduced FCGR3B copy number is associated with increased risk of systemic lupus erythematosus (SLE)
  • association of FCGR3B copy number with susceptibility to idiopathic pulmonary fibrosis
  • role of FCGR3B deletion in the aetiology of non-organ-specific autoimmune diseases, particularly SLE
  • low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS