Symbol
| CCR7
| contributors: mct - updated : 05-02-2015
|
HGNC name
| chemokine (C-C motif) receptor 7
|
HGNC id
| 1608
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in breast cancer cells, malignant breast tumors and metastases | tumoral
|  
|  
| --over
|  
|
in muscle fibers in juvenile dermatomyositis | constitutional
|  
|  
| --over
|  
|
of CCL5 and median chemokine receptor 7 (CCR7) mRNA expression in localized scleroderma lesions as compared to healthy controls | tumoral
|  
|  
| --over
|  
|
significantly increased in gastric adenocarcinomas compared to peritumoral tissue | constitutional
|  
|  
| --over
|  
|
exacerbates atherosclerosis by increasing T cell accumulation in atherosclerotic lesions | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis |
| | |
| CCR7-/- mice exhibit profound anomalies in lymph node and spleen architecture, which complicates the study of CCR7-mediated T cell trafficking |