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FLASH GENE
Symbol CCR7 contributors: mct - updated : 05-02-2015
HGNC name chemokine (C-C motif) receptor 7
HGNC id 1608
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer cells, malignant breast tumors and metastases
tumoral     --over  
in muscle fibers in juvenile dermatomyositis
constitutional     --over  
of CCL5 and median chemokine receptor 7 (CCR7) mRNA expression in localized scleroderma lesions as compared to healthy controls
tumoral     --over  
significantly increased in gastric adenocarcinomas compared to peritumoral tissue
constitutional     --over  
exacerbates atherosclerosis by increasing T cell accumulation in atherosclerotic lesions
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis
ANIMAL & CELL MODELS
  • CCR7-/- mice exhibit profound anomalies in lymph node and spleen architecture, which complicates the study of CCR7-mediated T cell trafficking