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FLASH GENE
Symbol FCGR2B contributors: mct - updated : 13-02-2015
HGNC name Fc fragment of IgG, low affinity IIb, receptor for (CD32)
HGNC id 3618
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
translocation in malignant lymphoma
constitutional     --low  
in memory B cells from SLE patients, reflecting inadequate inhibitory signaling in SLE memory B cells
Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to malaria
  • Variant & Polymorphism SNP
  • I232T increased in SLE patients (decreasing affinity to lipid rafts and attenuating inhibitory effects on B cell receptor signaling)
  • homozygous -343 C/C genotype in the promoter is more frequent in SLE patients
  • 343G/C promoter polymorphism associated with SLE
  • a SNP abrogates receptor function and is strongly associated with susceptibility to SLE, but also associated with substantial protection against severe malaria (Willcocks 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS