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FLASH GENE
Symbol TIE1 contributors: mct - updated : 07-12-2013
HGNC name tyrosine kinase with immunoglobulin and epidermal growth factor homology domains
HGNC id 11809
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in myeloid leukemia with early chronic phase and shorter survival
constitutional     --low  
in serum may serve as a marker of proliferative vasculopathy in systemic sclerosis (SSc) with disease duration of >6 years
tumoral     --low  
endothelial-mesenchymal transition (EndMT) associated with TIE1 downregulation participates in the pathological development of stroma observed in tumours
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS