Symbol
| SHC1
| contributors: mct/npt/pgu - updated : 13-03-2020
|
HGNC name
| SHC (Src homology 2 domain containing) transforming protein 1
|
HGNC id
| 10840
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin resistance | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| ITGA2B, ITGA8, GIT1, and SHC1 were identified as independent prognostic factors of overall survival of clear cell renal cell carcinoma | |
might act as a new biomarker and a diagnostic tool to identify membranous lupus nephritis with other membranous nephropathy (MN) | Therapy target
| | |
| p66Shc (-/-) diabetic mice show significantly less cognitive dysfunction and decreased levels of oxidative stress (OS) and the numbers of microglia |