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FLASH GENE
Symbol SHC1 contributors: mct/npt/pgu - updated : 13-03-2020
HGNC name SHC (Src homology 2 domain containing) transforming protein 1
HGNC id 10840
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin resistance
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • ITGA2B, ITGA8, GIT1, and SHC1 were identified as independent prognostic factors of overall survival of clear cell renal cell carcinoma
  • might act as a new biomarker and a diagnostic tool to identify membranous lupus nephritis with other membranous nephropathy (MN)
  • Therapy target
    ANIMAL & CELL MODELS
  • p66Shc (-/-) diabetic mice show significantly less cognitive dysfunction and decreased levels of oxidative stress (OS) and the numbers of microglia