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FLASH GENE
Symbol CTSS contributors: mct - updated : 06-10-2015
HGNC name cathepsin S
HGNC id 2545
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in lung tumor in progression
constitutional     --over  
in obese woman and reduced after gastric surgery-induced weight loss
constitutional       loss of function
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture
constitutional       gain of function
in psoriatic keratinocytes
Susceptibility
Variant & Polymorphism
Candidate gene a potential candidate gene in obesity
Marker
  • CTSS activity in tears can be measured in a simple, quick, economical, and noninvasive manner and may serve as a novel biomarker for autoimmune dacryoadenitis during the diagnostic evaluation for Sjögren syndrom
  • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    cathepsin S inhibitors are under clinical evaluation for diseases with impaired immune response, such as asthma and rheumatoid arthritis and could be tested in obese subjects, if cathepsin S inhibition proved to be of therapeutic relevance for obesity-lin
    cancerdigestiveliver
    CTSS silencing by lentivirus mediated RNAi provides an attractive anti-cancer strategy and a novel strategy for the treatment of human HCC
    cancer  
    therapeutic target in cancer
    ANIMAL & CELL MODELS