Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CTSS

contributors: mct - updated : 06-10-2015

HGNC name	cathepsin S
HGNC id	2545

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in lung tumor in progression constitutional     --over   in obese woman and reduced after gastric surgery-induced weight loss constitutional       loss of function cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture constitutional       gain of function in psoriatic keratinocytes

Susceptibility

Variant & Polymorphism

Candidate gene	a potential candidate gene in obesity
Marker	CTSS activity in tears can be measured in a simple, quick, economical, and noninvasive manner and may serve as a novel biomarker for autoimmune dacryoadenitis during the diagnostic evaluation for Sjögren syndrom
Therapy target
	System Type Disorder Pubmed obesity     cathepsin S inhibitors are under clinical evaluation for diseases with impaired immune response, such as asthma and rheumatoid arthritis and could be tested in obese subjects, if cathepsin S inhibition proved to be of therapeutic relevance for obesity-lin cancer digestive liver CTSS silencing by lentivirus mediated RNAi provides an attractive anti-cancer strategy and a novel strategy for the treatment of human HCC cancer     therapeutic target in cancer

ANIMAL & CELL MODELS